Novel Cardiac Markers for Pathophysiology- myassignmenthelp.com

Question: Pick Any Of The Traditional Or Novel Cardiac Markers And Describe Its Relevancy In Terms Of Pathophysiology And Pathology. Answer: Myoglobin is one of the essential cardiac markers available. However, it size is basically small at 17.8 kDa (Vassiliadis et al., 2012). One essential function of myoglobin as a biomarker is the transportation of oxygen through the muscles. Myoglobin is made up of approximately two percent of muscle protein and is found in both skeletal and cardiac muscles (Vassiliadis et al., 2012). Myoglobin ration is high in the plasma and tissue .In association with the size of myoglobin, it essentially released very fast in the circulatory system in cases of tissue necrosis and injury. In the development of cardiovascular disease, myoglobin is mainly recognized to be the earliest or latest biomarker to appear in the early stages of the disease (Vassiliadis et al, 2012). In cases of acute myocardial infraction, elevated levels of myoglobin are observed during the first thirty minutes to two hours. Conversely, since myoglobin is mainly released during cases of necrosis and tissue injury, it is not the most suitable biomarker for acute cardiac ischemia (Al-Hadi et al., 2009). It is essentially a poor biomarker when it comes to considering the existence of an acute cardiac ischemia. In addition to this deficit, it is important to note that myoglobin exhibits similar structure and morphology within skeletal and myocardial muscles. There is a one hundred percent similarity in the structure of myoglobin from both skeletal and myocardial muscles. Myoglobin is essentially cleared through from the body through the kidneys. In many instances those patients with kidney dysfunction will have very high readings. Current management guidelines stress that the patients with chest pan are tested for myoglobin biomarkers within the first six hours of onset of pain (Vassiliadis et al, 2012). References Vassiliadis, E., Barascuk, N., Didangelos, A., Karsdal, M. A. (2012). Novel cardiac-specific biomarkers and the cardiovascular continuum.Biomarker insights,7, BMI-S9536. Al-Hadi, H. A., Fox, K. A. (2009). Cardiac markers in the early diagnosis and management of patients with acute coronary syndrome.Sultan Qaboos University Medical Journal,9(3), 231.